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PhysioEx 9.1 Excersize 4: Activity 1
Human Physiology (PHYO 31)
El Camino College
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Name: Alison Lyons
Exercise 4: Endocrine System Physiology: Activity 1: Metabolism and Thyroid Hormone Lab Report
Pre-lab Quiz Results You scored 100% by answering 6 out of 6 questions correctly.
Which of the following statements about metabolism is false? You correctly answered: d. All of the energy from metabolism is ultimately stored in the chemical bonds of ATP.
Thyroxine is You correctly answered: c. the most important hormone for maintaining the metabolic rate and body temperature.
Thyroid-stimulating hormone (TSH) is You correctly answered: b. produced in the pituitary gland.
An injection of TSH to an otherwise normal animal will cause which of the following? You correctly answered: d. goiter development
Thyrotropin-releasing hormone (TRH) is You correctly answered: a. secreted by the hypothalamus.
Which of the following statements is true? You correctly answered: b. The hypothalamus primarily secretes tropic hormones that stimulate the secretion of other hormones.
Experiment Results Predict Question: Predict Question 1: Make a prediction about the basal metabolic rate (BMR) of the remaining rats compared with the BMR of the normal rat you just measured. Your answer : b. The hypophysectomized (Hypox) rat's BMR will be higher than the normal rat's BMR.
Predict Question 2: What do you think will happen after you inject thyroxine into the three rats? Your answer : a. The normal rat will become hyperthyroidic and develop a goiter.
Predict Question 3: What do you think will happen after you inject TSH into the three rats? Your answer : c. The injection will have no effect on the hypophysectomized rat and, therefore, it will not develop a goiter.
Predict Question 4: Propylthiouracil (PTU) is a drug that inhibits the production of thyroxine by blocking the attachment of iodine to tyrosine residues in the follicle cells of the thyroid gland (iodinated tyrosines are linked together to form thyroxine). What do you think will happen after you inject PTU into the three rats? Your answer : a. The normal rat will become hyperthyroidic and develop a goiter.
Stop & Think Questions: 1h. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 426 ml O2/hr
1i. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 106 ml O2/kg/hr
2h. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 384 ml O2/hr
2i. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
4d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1704 ml O2/kg/hr
5c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 384 ml O2/hr
5d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1573 ml O2/kg/hr
6c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 378 ml O2/hr
6d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1542 ml O2/kg/hr
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the thyroxine injection.
The normal rat is Your answer : b. euthyroid
Correct answer: c. hyperthyroid
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the thyroxine injection.
The thyroidectomized (Tx) rat is Your answer : a. hypothyroid Correct answer: c. hyperthyroid
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the thyroxine injection.
The hypophysectomized (Hypox) rat is You correctly answered: c. hyperthyroid
Which of the rats developed a goiter after injection with thyroxine (select all that apply)? You correctly answered: d. None of the rats developed a goiter with this injection.
7c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 378 ml O2/hr
7d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1704 ml O2/kg/hr
8c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 384 ml O2/hr
8d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 426 ml O2/hr
10d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1704 ml O2/kg/hr
11c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 384 ml O2/hr
11d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1573 ml O2/kg/hr
12c. Calculate the oxygen consumption per hour for this rat using the following equation.
ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour
Enter the oxygen consumption per hour in the field below and then click Submit Data to display your results in the Lab Report. You answered: 378 ml O2/hr
12d. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation).
Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr
Enter the metabolic rate in the field below and then click Submit Data to display your results in the Lab Report. You answered: 1542 ml O2/kg/hr
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the PTU injection.
The normal rat is You did not answer this question. Correct answer: a. hypothyroid
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the PTU injection.
The thyroidectomized (Tx) rat is You correctly answered: a. hypothyroid
Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid levels; BMR above 1800) after the PTU injection.
The hypophysectomized (Hypox) rat is You correctly answered: a. hypothyroid
Which of the rats developed a goiter after injection with PTU (select all that apply)? Your answer : d. None of the rats developed a goiter with this injection. Correct answer: a. the normal rat
Experiment Data:
Rat Weight (g) ml O2/min ml O2/hr BMR (ml O2/kg/hr)
Palpation Injected
Normal 250 7 426 1704 No Mass none Tx 244 6 384 1573 No Mass none Hypox 245 6 378 1542 No Mass none Normal 250 7 426 1704 No Mass none Tx 244 6 384 1573 No Mass none Hypox 245 6 378 1542 No Mass none Normal 250 7 426 1704 No Mass none Tx 244 6 384 1573 No Mass none Hypox 245 6 378 1542 No Mass none Normal 250 7 426 1704 No Mass none Tx 244 6 384 1573 No Mass none Hypox 245 6 378 1542 No Mass none
Review Sheet Results
- Part 1: Determining the Basal Metabolic Rates
Which rat had the fastest basal metabolic rate (BMR)? Your answer: The normal rat with thyroxine.
Why did the metabolic rates differ between the normal rat and the surgically altered rats? How well did the results compare with your prediction? Your answer: My prediction was wrong, the surgically altered rats have a fucntioning thyroid gland
If an animal has been thyroidectomized, what hormone(s) would be missing in its blood? Your answer: Thyroxine
If an animal has been hypophysectomized, what effect would you expect to see in the hormone levels in its body? Your answer: Decreased metabolic rate because of no thyroxine production
Part 2: Determining the Effect of Thyroxine on Metabolic Rate
What was the effect of thyroxine injections on the normal rat's BMR? Your answer: I was wrong, the TX rat had an increased BMR and the does was too large for it
What was the effect of thyroxine injections on the thyroidectomized rat's BMR? How does the BMR in this case compare with the normal rat's BMR? Was the dose of thyroxine in the syringe too large, too small, or just right? Your answer: I was wrong, the hypophysectimized rat increased, therefore making it hyperthyrodic. The does ended up being to high.
What was the effect of thyroxine injections on the hypophysectomized rat's BMR? How does the BMR in this case compare with the normal rat's BMR? Was the dose of thyroxine in the syringe too large, too small, or just right? Your answer: The hypophysectimized rat increased, therefore making it hyperthyrodic. The does ended up being to high.
Part 3: Determining the Effect of TSH on Metabolic Rate
What was the effect of thyroid-stimulating hormone (TSH) injections on the normal rat's BMR? Your answer: Overstimulation of the thyroid gland to secrete thyroxine increased BMR
What was the effect of TSH injections on the thyroidectomized rat's BMR? How does the BMR in this case compare with the normal rat's BMR? Why was this effect observed? Your answer: It had no effect on the throidectimized rat BMR. It is lower than normal rat because there was no thyroid to be stimulated
What was the effect of TSH injections on the hypophysectomized rat's BMR? How does the BMR in this case compare
with the normal rat's BMR? Was the dose of TSH in the syringe too large, too small, or just right? Your answer: It increased BMR because the thyroid was stimulated by TSH. This made the rat hypothyroidic and similar to the effect of the normal rat. The dose was too large thats why it cause that.
PhysioEx 9.1 Excersize 4: Activity 1
Course: Human Physiology (PHYO 31)
University: El Camino College
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