Therapeutic: Competes for H 1 -receptor sites on effector cells, thus blocking histamine release.

Pharmacologic: ANTIHISTAMINE; H1-RECEPTOR ANTAGONIST Pregnancy Category: C INDICATIONS Temporary symptomatic relief of various allergic conditions and to treat or prevent motion sickness, vertigo, and reactions to blood or plasma in susceptible patients. Also used in anaphylaxis as adjunct to epinephrine and other standard measures after acute symptoms have been controlled; in treatment of parkinsonism and drug-induced extrapyramidal reactions; as a nonnarcotic cough suppressant; as a sedative-hypnotic; and for treatment of intractable insomnia. DOSAGE/RANGE Route & Dosage Allergy Symptoms, Antiparkinsonism, Motion Sickness, Nighttime Sedation Adult: PO 25–50 mg t.i. or q.i. (max: 300 mg/d) IV/IM 10–50 mg q4–6h (max: 400 mg/d) Child: PO/IV/IM 2–6 y, 6 mg q4–6h (max: 300 mg/24 h); 6–12 y, 12–25 mg q4–6h (max: 300 mg/ h). Nonproductive Cough Adult: PO 25 mg q4–6h (max: 100 mg/d) Child: PO 2–6 y, 6 mg q4–6h (max: 25 mg/24 h); 6–12 y, 12 mg q4–6h (max: 50 mg/24 h) SIDE EFFECTS CNS: Drowsiness, dizziness, headache, fatigue, disturbed coordination, tingling, heaviness and weakness of hands, tremors, euphoria, nervousness, restlessness, insomnia; confusion; (especially in children): excitement, fever. CV: Palpitation, tachycardia, mild hypotension or hypertension, cardiovascular collapse. Special Senses: Tinnitus, vertigo, dry nose, throat, nasal stuffiness; blurred vision, diplopia, photosensitivity, dry eyes. GI: Dry mouth, nausea, epigastric distress, anorexia, vomiting, constipation, or diarrhea. Urogenital: Urinary frequency or retention, dysuria. Body as a Whole: Hypersensitivity (skin rash, urticaria, photosensitivity, anaphylactic shock). Respiratory: Thickened bronchial secretions, wheezing, sensation of chest tightness_._

NURSING CONSIDERATIONS

Assessment & Drug Effects

Monitor cardiovascular status especially with pre-existing cardiovascular disease. Monitor for adverse effects especially in children and the older adult. Supervise ambulation and use side-rails as necessary. Drowsiness is most prominent during the first few days of therapy and often disappears with continued therapy. Older adults are especially likely to manifest dizziness, sedation, and hypotension. Patient & Family Education

Do not use alcohol and other CNS depressants because of the possible additive CNS depressant effects with concurrent use. Do not drive or engage in other potentially hazardous activities until the response to drug is known. Increase fluid intake, if not contraindicated; drug has an atropine-like drying effect (thickens bronchial secretions) that may make expectoration difficult. Do not breast feed while taking this drug.

MEDICATION CARD – LILIAN THIMOTTI

POSTPARTUM

DIPHENHYDRAMINE BENADRYL

GENERIC NAME TRADE NAME

CLASSIFICATION

Therapeutic: Competes for H1-receptor sites on effector cells, thus blocking histamine release.

Pharmacologic: ANTIHISTAMINE; H1-RECEPTOR ANTAGONIST

Pregnancy Category: C

INDICATIONS Temporary symptomatic relief of various allergic conditions and to treat or prevent motion

sickness, vertigo, and reactions to blood or plasma in susceptible patients. Also used in anaphylaxis as

adjunct to epinephrine and other standard measures after acute symptoms have been controlled; in

treatment of parkinsonism and drug-induced extrapyramidal reactions; as a nonnarcotic cough

suppressant; as a sedative-hypnotic; and for treatment of intractable insomnia.

DOSAGE/RANGE

Route & Dosage

Allergy Symptoms, Antiparkinsonism, Motion Sickness, Nighttime Sedation

Adult: PO 25–50 mg t.i.d. or q.i.d. (max: 300 mg/d) IV/IM 10–50 mg q4–6h (max: 400 mg/d)

Child: PO/IV/IM 2–6 y, 6.25 mg q4–6h (max: 300 mg/24 h); 6–12 y, 12.5–25 mg q4–6h (max: 300 mg/24

h).

Nonproductive Cough

Adult: PO 25 mg q4–6h (max: 100 mg/d)

Child: PO 2–6 y, 6.25 mg q4–6h (max: 25 mg/24 h); 6–12 y, 12.5 mg q4–6h (max: 50 mg/24 h)

SIDE EFFECTS

CNS: Drowsiness, dizziness, headache, fatigue, disturbed coordination, tingling, heaviness and weakness

of hands, tremors, euphoria, nervousness, restlessness, insomnia; confusion; (especially in children):

excitement, fever. CV: Palpitation, tachycardia, mild hypotension or hypertension, cardiovascular

collapse. Special Senses: Tinnitus, vertigo, dry nose, throat, nasal stuffiness; blurred vision, diplopia,

photosensitivity, dry eyes. GI: Dry mouth, nausea, epigastric distress, anorexia, vomiting, constipation, or

diarrhea. Urogenital: Urinary frequency or retention, dysuria. Body as a Whole: Hypersensitivity (skin

rash, urticaria, photosensitivity, anaphylactic shock). Respiratory: Thickened bronchial secretions,

wheezing, sensation of chest tightness.

Diphenhydramine MED CARD

Maternal Child Nursing (NUR 104)

Mount Wachusett Community College

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