Imperial College London

Select the INCORRECT answer. Antimuscarinic drugs such as atropine cause all of the following effects except:

Question 5Select one:

a.

Bronchoconstriction

b.

Pupil dilation (mydrasis)

c.

Urinary retention

d.

Dry mouth

e.

Tachycardia

Select the INCORRECT statement. All of the following events occur as a result of stimulation of M2 muscarinic acetylcholine receptors in the heart except:

Question 4Select one:

a.

Decrease in intracellular cAMP levels

b.

Increase opening of voltage-gated potassium channels

c.

Stimulation of G-protein coupled signalling cascades

d.

Stimulation of adenylate cyclase activity

e.

Reduction in the rate and force of heart contraction

Select the correct statement describing the actions of atropine:

Question 3Select one:

a.

Atropine causes bradycardia

b.

Atropine is a selective nicotinic acetylcholine receptor antagonist

c.

Atropine will reduce peristalsis in the gastrointestinal tract

d.

Atropine is a selective muscarinic acetylcholine receptor agonist

e.

Atropine will lead to excessive sweating

Select the correct statement. The therapeutic index of a drug is defined as the :

Question 2Select one:

a.

0.693/t ½

b.

Drug concentration which gives a 50 % maximal response

c.

Ratio of LD50/Drug clearance

d.

Ratio of ED50/LD50

e.

Ratio of LD50/ED50

Select the statement that most accurately describes secondary carcinogens:

Question 1Select one:

a.

Secondary carcinogens are converted to reactive metabolites by glucuronidation reactions

b.

Alkylating agents form a major class of secondary carcinogen

c.

Benzo-a-pyrene is a major inhibitor of secondary carcinogen production

d.

The body uses cytochrome P450 activity to reduce secondary carcinogen formation

e.

Secondary carcinogens must be converted to reactive metabolites before they are able to form complexes with DNA