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Mutations - WS - KEY - Sonal Tonger
Course: Human Anatomy and Physiology 1 (BIOL 2401)
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University: Lone Star College System
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Delahunty/Biology Honors Mutations Worksheet Name KEY
There are several types of mutation:
DELETION (a base is lost)
INSERTION (an extra base is inserted)
Deletion and insertion may cause what’s called a FRAMESHIFT, meaning the reading “frame”
changes, changing the amino acid sequence.
SUBSTITUTION (one base is substituted for another)
If a substitution
changes
the amino acid, it’s called a MISSENSE mutation.
If a substitution
does not change
the amino acid, it’s called a SILENT mutation.
If a substitution
changes the amino acid to a “stop,”
it’s called a NONSENSE mutation.
Complete the boxes below. Classify each as either Deletion, Insertion, or Substitution AND as either
frameshift, missense, silent or nonsense (hint: deletion or insertion will always be frameshift).
Original DNA Sequence:T A C A C C T T G G C G A C G A C T
mRNA Sequence: A U G U G G A A C C G C U G C U G A
Amino Acid Sequence: METHIONINE -TRYPTOPHAN - ASPARAGINE - ARGININE- CYSTEINE - (STOP)
Mutated DNA Sequence #1: T A C A T C T T G G C G A C G A C T
What’s the mRNA sequence? A U G U A G A A C C G C U G C U G A (Circle the change)
What will be the amino acid sequence? METHIONINE -(STOP)
Will there likely be effects? YES What kind of mutation is this? SUBSTITUTION - NONSENSE
Mutated DNA Sequence #2: T A C G A C C T T G G C G A C G A C T
What’s the mRNA sequence? A U G C U G G A A C C G C U G C U G A (Circle the change)
What will be the amino acid sequence? METHIONINE - LEUCINE -GLUTAMIC ACID – PROLINE
Will there likely be effects? YES What kind of mutation is this? INSERTION - FRAME SHIFT
Mutated DNA Sequence #3: T A C A C C T T A G C G A C G A C T
What’s the mRNA sequence? A U G U G G A A U C G C U G C U G A (Circle the change)
What will be the amino acid sequence? METHIONINE-TRYPTOPHAN-ASPARAGINE- ARGININE- (STOP)
Will there likely be effects? NO What kind of mutation is this? SUBSTITUTION – SILENT MUTATION
Mutated DNA Sequence #4: T A C A C C T T G G C G A C T A C T
What’s the mRNA sequence? A U G U G G A A C C G C U G A U G A (Circle the change)
What will be the amino acid sequence? METHIONINE-TRYPTOPHAN-ASPARAGINE- (STOP)
Will there likely be effects? YES What kind of mutation is this? SUBSITUTION - NONSENSE
Original DNA Sequence:T A C A C C T T G G C G A C G A C T
A U G U G G A A C C G C U G C U G A
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