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Chlorpromazine - Drug template
Course: Principles of Pharmacology/Medicinal Chemistry/Toxicology (PHM 321)
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University: Long Island University
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ACTIVE LEARNING TEMPLATES THERAPEUTIC PROCEDURE A7
Medication
STUDENT NAME _____________________________________
MEDICATION __________________________________________________________________________ REVIEW MODULE CHAPTER ___________
CATEGORY CL ASS ______________________________________________________________________
ACTIVE LEARNING TEMPLATE:
PURPOSE OF MEDICATION
Expected Pharmacological Action
Complications
Contraindications/Precautions
Interactions
Medication Administration
Evaluation of Medication Effectiveness
Therapeutic Use
Nursing Interventions
Client Education
Joshua Cohen
Chlorpromazine
Conventional antipsychotic
-Block norepinephrine, acetylcholine,
dopamine, and histamine receptors.
-Give oral dose with food and/or full glass of
water to preven GI effects
-Have patient swallow sustained release form
whole
-Give IM injection in large muscle; rotate sites
-Keep patient recumbent for 30 minutes after IM
or IV dose due to possible hypotension
-IV form incompatible in solution with multiple
drugs
-Give IV bolus no faster than 1mg/minute
-CNS depressants increase sedation
-Antacids and antidiarrhealsspace 2 hours from
chlorpromazine administration due to poor absorption
-Decreased blood level of antiseizure drugs
Contraindications:
-Allergy to phenothiazine antipsychotic drugs
-Alcohol withdrawal
-Bone marrow suppression
Precautions:
-Diabetes mellitus
-Hypertension
-Prostatic Hypertrophy
-Akathisia: occurs within first 2 months of therapy
-Parkinson-like symptoms may occur within first month of therapy
-Acute dystonia-- occurs hours to days following first dose
-Tardive dyskinesia-- occurs months to years after therapy begins
-Suppresses symptoms of schizophrenia
-Acute manic phase of bipolar disorder
-Relieves nausea/vomiting
-Intractable hiccups
-Treat with beta blocker or benzodiazepine;
possibly switch to an atypical antipsychotic
-Treat on short-term basis with
anti-Parkinson
drugs
-Be prepared to administer IM or IV
anticholinergic, such as diphenhydramine
-Prevention of acute psychotic maifestations, absence of
hallucinations, delusions, anxiety, and hostility
-Ability to perform ADLs
-Ability to interact socially with peers
-Sleeping and eating habits
-Notify for feelings of inner restlessness, inability
to sit still; muscle rigidity, tremors, and sluggish
movements, drooling, and shuffling gait occur;
sever spasms of the neck and body; involuntary
movements of tongue, face, limbs, trunk.
-Chew gum or suck hard candy to treat dry
mouth, increase fluids/fiber to prevent
constipation; urinate just before taking drug dose
-Wear gloves when handling phenothiazines;
avoid sun exposure; report sudden fever