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Buccal Sublingual Drug Delivery Systems
Pharmaceutic II (PHAR 636)
West Coast University
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Describe the two types of oral transmucosal routes for drug delivery and Explain the differences in absorption characteristics between buccal & sublingual delivery.
Buccal & Sublingual Drug Delivery
Systems
Saturday, March 4, 2023 5:38 PM
List the formulation factors that can affect drug absorption by the buccal and sublingua routes.
Sublingual - best onset of action biggest advantage Fast-dissolving tablet ○ Protect from heat, light and moisture
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Products can contain Lactose monohydrate, Glyceryl monostearate, pregelatinized starch, calcium steerage, NF powder, silicon dioxide and colloidal.
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Excipients more hydrophilic or hydrophobic? Hydrophilic, because under the tongue you need to have fast dissolution
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Spray ○ NitroMist
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Products can contain Capellini/capric diglycerol succinct, pappermint oil, menthol, and n- butane
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Buccal - for proteins, we need contact time Buccal tables Fentora Releases CO2(effervescent) to help with transient delivery(permeation enhancement)
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Transient decrease in pH to optimize dissolution & increase in pH for membrane permeation
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Buccal patch ○ Onsolis Buccal patch
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Onsolis Buccal patch § For more drug, surface area is increased not mg dose. Mucoadhesive is critical for enhanced contact time with the Buccal epithelia
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BOTH: no first pass
Identify the two main advantages of transmucosal delivery
- Protein & peptide delivery is possible
- Bypass’s first pass metabolism
Surface area:
Buccal Sublingual Drug Delivery Systems
Course: Pharmaceutic II (PHAR 636)
University: West Coast University
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