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Medical Technology (MedTech)
Centro Escolar University
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3: Hematology I Leukocytes: Laboratory Determinations Questions 247 MLS ONLY 248 MLS ONLY 249 MLS ONLY 250 251 MLS ONLY Which substrate is used for the detection of specific esterase? a acetate 1) chloroacetate c pararosanilin acetate d phenylene diacetate A useful chemical test for the diagnosis of hairy cell leukemia is the: a peroxidase test 1) Sudan black test c periodic acid—Schiff test d tartrate—resistant acid phosphatase test Cytochemical stains were performed on bone marrow smears from an acute leukemia patient. All blasts were periodic acid—Schiff (PAS) negative. The majority of the blasts showed varying amounts of Sudan black B positivity. Some of the blasts stained positive for naphthol AS—D acetate esterase, some were positive for naphthol AS—D chloroacetate esterase, and some blasts stained positive for both esterases. What type of leukemia is indicated? a lymphocytic b myelogenous c myelomonocytic d erythroleukemia Which of the following stains is closely associated with the lysosomal enzyme in primary (azurophilic) granules? a peroxidase b Sudan black B c periodic acid—Schiff (PAS) d Prussian blue What feature would not be expected in pseudo—Pelger—Huét cells? a hyperclumped chromatin 1) decreased granulation c normal peroxidase activity d normal neutrophils Clinical Laboratory Certification Examinations 1853: Hematology l Leukocytes:Laboratory Determinations Questions 252 A 30—year—old woman was admitted to the hospital for easy bruising and menorrhagia. Laboratory gfiY findings included the following: WBC: 3 103/uL (35X 10%) R80: 2/pL (2 x1012/L) Plt: 30 x1O3/uL(30/L) Hgb: 8 g/dL (86 g/L) Hct: 25% MCV: 100 um3 (100 fL) MCH: 34 pg MCHC: 34% PT: 34 sec APTT: 62 sec TT: 15 sec FSP: &amp;gt;40 ug/mL (&amp;gt;40 mg/L) fibrinogen: 815 mg/dL (3 g/L) (control 200-400 mg/dL [2—4 g/L]) Differential: Polys: 3% Lymphs: % Monos: 2% Myelos: 4% Abnormal immature: 58% Blasts: 31% nRBC: 1 Auer bodies, 1+ macrocytes, 1+ polychromasia The cells identified as &amp;quot;abnormal immature&amp;quot; were described as having lobulated nuclei with prominent nucleoli; the cytoplasm had intense azurophilic granulation over the nucleus, with some cells containing 1—20 Auer bodies, frequently grouped in bundles. A 15—17 chromosomal translocation was noted. Cells were SBB, peroxidase and NAS—D—chloroacetate positive, PAS negative. Which of the following types of acute leukemia is most likely? a myeloblastic b promyelocytic c myelomonocytic d monocytic 253 Which of the following leukemias is characterized by immature cells that are Sudan black B 3,55” positive with discrete fine granules, peroxidase negative, PAS variable, strongly alpha naphthyl acetate esterase positive, and muramidase positive? acute lymphocytic chronic lymphocytic acute myelocytic acute myelomonocytic fl-fiU‘D 254 Chronic lymphocytic leukemia cells are most likely to express which of the following cell MLS ONLY surface markers? 21 CD3, CD7, CD19 and CD20 b CD19, CD20, CD4 and CD5 c CD19, CD20, CD21, CD5 (1 CD13, CD33, CD107 255 Which of the following markers, typically detected in normal myeloid cells, are expressed on the 2,“ng surface of hairy cell leukemia lymphocytes? a CD3 b CD8 c CD11c d CD103 185 The Board of Certification Study Guide3: Hematology I Platelets: Physiology Questions 264 Which of the following cells contain hemosiderin? a megakaryocyte b osteoclast c histiocyte d mast cell 265 Which of the following cells is the largest cell in the bone marrow: a megakaryocyte b histiocyte c osteoblast d mast cell 266 Normal platelets have a circulating life—span of approximately: a 5 days I) 10 days c 20 days (1 30 days 267 Aspirin affects platelet function by interfering with platelets' metabolism of: MLS 0”” a prostaglandins b lipids c carbohydrates (1 nucleic acids 268 The combination of increased capillary fragility and prolonged bleeding time suggests a MLS - - , ONLY defic1ency in. a thromboplastin b prothrombin ‘c platelets d fibrinogen 269 Platelet activity is affected by: a calcium 1) aspirin c hyperglycemia d hypoglycemia 270 Cells involved in hemostasis are: a erythrocytes b granulocytes c lymphocytes d thrombocytes 271 Alpha granules are found on the platelet in: MLS ONLY peripheral zone sol gel zone organelle zone membranes mnu'm 188 The Board of Certification Study Guide3: Hematology I Platelets: Disease States Questions Platelets: Disease States 272 Thrombocytopenia is a characteristic of: MLS ONLY 3 classic von Willebrand disease b hemophiliaA c Glanzmann thrombasthenia d May—Hegglin anomaly 273 Which of the following is a true statement about acute idiopathic thrombocytopenic MLS ONLY purpura (ITP)? a it is found primarily in adults I)‘ spontaneous remission usually occurs within several weeks c women are more commonly affected d peripheral destruction of platelets is decreased 274 Which of the following is the most common cause of an abnormality in hemostasis? MLS ONLY a decreased plasma fibrinogen level b decreased Factor VIII level c decreased Factor IX level d quantitative abnormality of platelets 275 The following results were obtained: MLS ONLY WBC: 1 x103/pL (1 109/L) Hgb: 8 g/dL (89 g/L) Hct: 27% Plt: 2,300 x103/pL (2 x109/L) LAP: 90 Differential: Segs: 70% Bands: 10% Lymphs: 18% Monos: 2% Giant, bizarre platelets, rare megakaryocytes 3+ Poikilocytosis, 2+ Anisocytosis 1+ Schizocytosis This is consistent with: a neutrophilic leukemoid reaction I) polycythemia vera c leukoerythroblastosis in myelofibrosis cl idiopathic thrombocythemia 276 A 53—year—old man was in recovery following a triple bypass operation. Oozing was noted from his 2,43,, surgical wound. The following laboratory data were obtained: Hemoglobin: 12 g/dL (125 g/L) Hematocrit: 37% Prothrombin time: 12 seconds APTT: 34 seconds Platelet count: 40 x103/pL(40/L) Fibrinogen: 250 mg/dL (2 g/L) The most likely cause of bleeding would be: a dilution of coagulation factors due to massive transfusion b intravascular coagulation secondary to microaggregates c hypofibrinogenemia d dilutional thrombocytopenia Clinical Laboratory Certification Examinations 189
Sample/practice exam, questions
Course: Medical Technology (MedTech)
University: Centro Escolar University
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